The proposed article presents theoretical studies of the treatment and prevention of intestinal infections of farm animals and birds. The relevance of the topic is due to the emergence and spread of infections resistant to antibiotics associated with the widespread use of antibiotics in clinical medicine, veterinary medicine and agriculture, which reduces the effectiveness of antibiotics in the fight against intestinal infectious diseases and their treatment

In this article we have studied the actual problems of the Republic of Kazakhstan in the field of legal regulation and counteraction to trafficking and drug addiction. The aim of the study was to study the problems leading to modern drug situation and determine the possibilities of their solution. The annual decrease of the registered acts in this area, at decrease of the solved crimes is established. There is an increase in synthetic drugs among young people, which go through the Internet. The results of counteraction to the fight against drugs were the elimination of organized criminal groups, detection of smuggling and legalization of income from drug trafficking and a set of preventive measures of various directions. It is proposed to continue to improve the legislation to ensure effective social and state control over synthetic and other drugs. To develop a comprehensive program aimed at the prevention of modern forms of drug addiction and the fight

The work is intended to determine the etiopathogenetic principles of animal prevention in gynecological pathology and issue a theoretical justification. At the same time, improving preventive measures aimed at preserving their health, increasing the productivity of animals in modern conditions of animal husbandry and ensuring high productivity of cows. In this regard, the main task is to develop ways to increase insemination of cows with the use of complex and homeopathic treatment. For the first time in the East Kazakhstan region, new scientific data on the main etiological factors leading to gynecological pathology and infertility of cows were obtained. Work has been carried out to improve measures aimed at preventing infertility of cows in the conditions of dairy farming in this region and stimulating increased insemination. New schemes for stimulating increased insemination using hormonal, homeopathic and other drugs have been tested. As a result, an increase in the productivity of cows was revealed, and stimulation schemes were introduced. For the first time in the farm" kamyshinskoye" an economic assessment of the damage from infertility of cows is given. Research work is done between 2016 and 2019 years by the Department of veterinary medicine of the State University named after Shakarim, in the laboratory "Agrotechnopark" of the State University named after Shakarim and national University of veterinary medicine and biotechnology named after Lviv and in the farm "kamyshinskoye" of the Shemonaikha district of East Kazakhstan region. To enhance the insemination of cows 3 groups of animals was obtained: animals of group I were not subjected to insemination; animals of group II for 1-3 hours before insemination grafted surfagon 3 ml (15 mg), 15 ml of Catosal, 15 ml habilita-Se, 10 ml uteroton; 8 days prior to insemination progesterone 2,5% 2 ml, Catosal 15 ml, habilita-Se 15 ml; cows of group III for 30-60 minutes before insemination were given Ovariovitis, and after fertilization Ovariovitis for 25-30 days and liarcine 5 ml. According to the results of drawings based on complex and homeopathic preparations, low costs were shown.

This article discusses the current data on the biochemical properties of bacteria of the genus Lactobacillus and their use in industry, particularly in dairy production and biotechnology. Microorganisms of the genus Lactobacillus have antagonistic activity against pathogenic microorganisms and perform an immunomodulatory function. The positive effect of lactobacilli on human health explains their active use in probiotics. The positive effects of normal intestinal microflora and probiotics are mainly due to bifidobacteria and lactobacilli. In probiotic therapy, various types of bacteria of the genus Lactobacillus are used, such as: L. acidophilus, L. rhamnosus, L. plantarum, L. fermentum, L. delbrueckii subsp. bulgaricus, L. casei, L. paracasei. In recent years, the biotechnology of probiotics has been intensively developing - drugs used for the correction and prevention of microecological disorders in the gastrointestinal tract of humans and animals. An urgent issue is obtaining new data on the biological properties of lactobacilli, creating new probiotic preparations based on them using modified approaches to cultivation. The results of determining the species L. acidophilus L. casei, L. rhamnosus, L. paracasei, obtained by the classical biochemical identification method based on saccharolytic activity, complicating species identification, are comparable to the molecular genetic method. In the case of L. casei, L. rhamnosus, L. paracasei, it is necessary to carry out modern identification methods based on the polymerase chain reaction, since their biochemical properties are similar, which makes it difficult to carry out species identification. The molecular genetic method is a valuable addition to the intergeneric and species identification of lactobacilli, given the variability of the classical biochemical method.

The variety of species and forms of parasites of agricultural animals and the features of their life cycles are the basic foundation for the production of different types and medical forms of antiparasite medicine. In the treatment of the parasitic diseases of agricultural animals, one of the main factors is that the veterinary doctors have the knowledge on the mechanics, efficiency and the safety for humans and environment of the medicine being used. Taking into account high pathogenicity and resistance of parasitic organisms and their ability to adapt to effect of medicine, it is crucial to permanently monitor the efficiency of the applied anthelmintic drugs, including the new drugs offered by veterinary services. This article will describe the results of the research on pharmacodynamic and pharmacokinetic parameters of «Ivermectinum», «Ivermec», «Aversect-1», «Аvrsect-2», «Аivin» drugs and their methods of application with the consideration of terms of maintenance and immune status of cattle herds in Mayconyr village (Irtysh district, Pavlodar region). A comparative analysis of efficiency of the above mentioned drugs in dehelmintization and treatment of cattle was conducted with the results provided. The recommendations and the restrictions on use of the drugs were determined considering the farm condition. The experimental research of the aforementioned broad-spectrum drugs was conducted strictly following the rules of asepsis and instructions on application. The total number of replacement heifers subjected to the dehelmintization under the method of analogues is 150 units. Anthelmintic treatment was conducted two times a year - in springtime (March-April) before pasturage, and fall time (September-October) before confining the cattle in the stable. Coprological study on intestinal helminthes of the examined cattle was conducted in Irtysh RVL of the Pavlodar regional branch of RVE RVL VCaSC MA RK by ovoscopical, flotation and larvoscopical methods. There is a comparative analysis on the efficiency of avermectin group antiparasitic drugs applied twice a year for cattle dehelmintization. The recommendations on the use of the aforementioned drugs for dehelmentization and prevention of parasitic diseases are provided and the requirements for the use were determined.

The degree of dаmаge to deer by the lаrvаe of Oedemаgenа tаrаndi of the Hypodermаtidаe fаmily depends on the number of femаles of the subcutаneous gаdfly in the summer. For the development of meаsures to combаt deer gаdflies, vаrious methods hаve been tested over the yeаrs, аmong them methods of wаtering аnd externаl locаl аpplicаtion. For this purpose, mаny reseаrchers tested dipterex (80 %), crystаlline chlorophos (97 %) in the form of аn 8 % solution, tiguvon, ricifon, dioxаfos, sulfidophos-20 аnd ectopor (2 % cypermethrin) аnd other drugs. Vаrbeks 35 %, Bаytex-50, Fenthion-50, Nаtаsol аnd Etаcid, etc. were tested intrаmusculаrly in vаrious doses on deer. The purpose is to study the prevаlence аnd effectiveness of the treаtment of edemаgenosis in sikа deer in the Ussuriysk urbаn district. The reseаrch wаs cаrried out аt the deer fаrm "Borisovskаyа". For the experiment, three groups of deer were formed with 6 heаds eаch. In order to study the therаpeutic аnd prophylаctic efficаcy of the two groups of drugs Аversect-2 аnd Dectomаx, the аnimаls of the first experimentаl group were injected with the drug Аversect-2 subcutаneously аt the rаte of 1 ml per 50 kg of аnimаl weight, deer of the second experimentаl group were injected subcutаneously with Dectomаx аt а dose of 0.2 mg per 1 kg of mаss, which corresponds to 1 ml of solution per 50 kg of mаss. The prepаrаtions were аdministered immediаtely аfter the end of the summer of gаdflies (end of July-beginning of Аugust). The third group of deer did not receive drugs, аnd it remаined the control group. The incidence of sikа deer entomosis in the Ussuriysk urbаn district for three yeаrs wаs quite high аnd remаined аt the sаme level for аlmost the entire period (43.21-48.8), with а slight decreаse in 2021 to 37.4 %, which wаs most likely due to the climаtic conditions of this period. Of the two selected drugs with seemingly the sаme spectrum of аction, the best results were obtаined on the deer of the second experimentаl group, where the drug "Dektomаx" wаs used, while the EI wаs significаntly (two times) lower thаn in the first experimentаl group аnd аmounted to 16.7 % versus 33. 3 %, аnd АI - 0.03, аgаinst 0.83.