The key problem in the investigation of serial crimes against personality is the destructive fragmentation and the lack of effective multidisciplinary interaction between investigation subjects, forensic experts, and practicing psychologists (profilers). The existing methodological gap leads to an underestimation of the behavioral and psychological traces of the crime, which are often perceived by investigators as secondary compared to the traditional physical evidence base (DNA, fingerprinting, ballistics). This creates a "tunnel vision" phenomenon among investigative teams, delays the establishment of the serial nature of crimes, limits the analytical potential of expert opinions, and, as a result, allows serial offenders to evade justice for years, increasing the number of victims. The purpose of the article is a comprehensive theoretical and methodological analysis of barriers to multidisciplinary interaction in the investigation of serial crimes against personality, identification of systemic defects in communication between investigative, forensic, and psychological institutions, as well as the development of a scientifically grounded model for integrating behavioral analysis into traditional investigation algorithms. Particular attention is paid to creating a unified methodological language for forensic scientists and psychologists, forming end-to-end interagency investigative-operational teams, and protecting expert independence from departmental pressure. The study utilizes comparative forensic, systemic-structural, formal-logical, and analytical methods, as well as a retrospective analysis of criminal case materials regarding serial murders and sexual violence. The methodological framework is based on the content analysis of relevant regulatory legal acts governing forensic expert activity, methodical recommendations on maintaining consolidated forensic records, as well as international and domestic protocols for constructing a searching psychological profile (profiling). The analysis revealed key problems: rigid departmental isolation of expert and investigative units, conceptual distrust of practitioners towards forensic psychological examination data, the lack of unified standards for fixing and interpreting the offender's "behavioral handwriting" (Modus Operandi) at the crime scene, and a shortage of qualified personnel possessing competencies at the intersection of forensics and deviantology. It has been established that to overcome these barriers, comprehensive measures are required: the implementation of end-to-end digital platforms for automatic cross-matching of physical and behavioral evidence from different regions, modernization of training programs for investigators in the field of forensic psychology, and the statutory consolidation of the status of a specialist profiler within the criminal procedure framework. Solving these problems will ensure rapid recognition of the serial nature of crimes at early stages, minimize the risk of expert errors (including confirmation bias), and significantly increase the clearance rate of latent encroachments on human life and property. Harmonization of interaction between science and investigative practice will strengthen the protection of society against the most dangerous criminal threats and increase public confidence in the effectiveness of the law enforcement system