This article analyzes the existing water treatment technologies and consider aspects of the effectiveness of implementation of reverse osmosis on TPP.

Today the clinical manifestation of enterobiosis is studied adequately. However, global environmental changes for the last decades, the widespread use of anthelmintic preparations, medications and number of other factors have changed the clinical data of parasitic infestations. Today a question of treatment of parasitic infestationsof children is not fully resolved. Despite the availability of a wide range of antiparasitic agents, they possess a lot of side effects. Moreover, currently, there is a tendency that many parasites develop tolerance for antiparasitic preparations. In this regard search methods for early, highly-qualified, informative and specific verification of helminth-parasitic infestation remain relevant in order tocarry out timely treatment with the methods, which have minimal side effects and possess high efficacy against parasitic infections of children.

Today the clinical manifestation of enterobiosis is studied adequately. However, global environmental changes for the last decades, the widespread use of anthelmintic preparations, medications and number of other factors have changed the clinical data of parasitic infestations. Today a question of treatment of parasitic infestationsof children is not fully resolved. Despite the availability of a wide range of antiparasitic agents, they possess a lot of side effects. Moreover, currently, there is a tendency that many parasites develop tolerance for antiparasitic preparations. In this regard search methods for early, highly-qualified, informative and specific verification of helminth-parasitic infestation remain relevant in order tocarry out timely treatment with the methods, which have minimal side effects and possess high efficacy against parasitic infections of children.

This article is written in line with the important questions on antimicrobial effects of natural honey against gram-positive bacteria to reveal the therapeutic properties. These circumstances demonstrate the medical and social significance of solving the science-oriented task of developing high-quality pharmaceutical product on the basis of honey as well as its application not only as a preventive and medicinal agent to treat many illnesses but also as in beauty treatment.

In this article the question connected with the activation of cognitive activity of students. It one of issues of the day on the modern stage of development of pedagogical theory and practice. An author exposes development of activity, independence, initiativeness, creative approach to the thing, these are the requirements of life, qualificatory that direction in that it is necessary to perfect an educational process in a great deal. Searches of ways of development of schoolchildren’s activation of cognitive activity, developing their cognitive flairs and independence is a task that teachers are called to decide. The use of ICТ, that allows to activate thinking, ability to offer the variants of vision of problem, question, themes in the narrow and wide understanding and participating in the discussion are examined in the article. It helps to improve quality education, forms a culture, aesthetic skills of students, develop attention, memory. All this has a practical orientation in different areas and spheres of activity of student. Information technologies, examined in this scientific article as a process of the use of totality of facilities, methods of collection, treatment and communication of data - assists working off at the methods of students of actions, helps forming of processes of self-government of personality, will transform an effectively-practical sphere and carries out the emotionally-semantic going near the study of questions, that discussions, professional orientation.

This article analyzes the essence of the concept of "packaging", made the systematization of approaches and the role of packaging in the course of treatment. According to research results, based on a critical analysis of the existing provisions of the creation of the package proposed by its own methodological tools, which brings together the work of the producers (designers, graphic designers) and marketers.

This article discusses the evaluation of the effectiveness of disinfectants «Dezosteril» and its derivatives and analogues in the fight against tuberculosis. The emergence of tuberculosis and its pathogens. Namely, «to Dezosteril» and its derivatives produced on the territory of «BO-NA» of Pavlodar city. The main attention is paid to the types and methods of disinfection. Resistance of microorganisms to chemical disinfectants based on peracetic acid (NUK) and hydrogen peroxide.

The proposed article presents theoretical studies of the treatment and prevention of intestinal infections of farm animals and birds. The relevance of the topic is due to the emergence and spread of infections resistant to antibiotics associated with the widespread use of antibiotics in clinical medicine, veterinary medicine and agriculture, which reduces the effectiveness of antibiotics in the fight against intestinal infectious diseases and their treatment

The article identifies and studies various fillers for fermented milk products with increased nutritional and biological value, presents methods of production of serum necessary for the development of a new therapeutic and prophylactic food product. The technical result is to improve the taste, increase the nutritional properties of the product, the introduction of the resulting whey drink fruit and berry additives in the form of syrup

This paper presents the results of the influence of ultrasonic treatment in the cofermentation of the cattle manure mixture (cattle) with the leaven from the rumen of ruminants on the process of biogas production. Anaerobic digestion was carried out in matinence periodic operation at the mesophilic temperature of 38 C ̊. As a substrate, a mixture with a content of 70 % cattle manure and 10 % leaven from rumen of ruminants was used. Treatment with ultrasound of the mixture was carried out at an intensity of 10 W/cm2 and an amount of input energy of 9350 kJ/kg of dry matter (DM), which completely eliminated the processes of stratification and sedimentation. Decomposition of organic matter (OM) in the periodic regime with the enzyme and ultrasound treatment occurred within 8 days, the usual substrate during this time OM decomposed 3.0 times less (only 14 %). The process of fermentation of methane in continuous and periodic modes treated with ultrasound, as at other temperatures, was stable, as can be judged by the values of volatile fatty acids (VFA) Volatile fatty acids (VFAs), alkalinity, pH, and biogas. The energetical efficiency of methane fermentation is estimated by comparing the volume of fuel (biogas) and heat consumption for technological needs. As shown by the comparison of efficiency of different regime, the largest amount of commercial energy in the form of biogas was obtained in the mode of joint fermentation of a mixture of cattle manure (cattle) with a ferment from the rumen of ruminants treated with ultrasound – 3 times more than without treatment (space).

Environmental protection measures are based, among other things, on the rationalization of the organization of the production waste management process. Population growth and the race to industrialize pose a serious threat to the ecosystem. Currently, the average global waste generation per capita is 494 kg / year. A large number of industrial enterprises operate on the territory of Kazakhstan. The range of manufactured products is very wide: household items, transport, building materials, equipment and much more. Each type of production is inevitably a source of a large amount of industrial waste, annually at the enterprises of Kazakhstan up to 600 million tons of waste are generated, three percent of which are recycled. On the territory of Pavlodar region there are enterprises in the field of metallurgy, mechanical engineering, chemical industry, construction industry enterprises, light industry, about a hundred in total. In this connection, the problem of treatment and disposal of industrial waste in Pavlodar region is very relevant. The article discusses the system of waste management in order to reduce their impact on the environment, activities for the disposal, transportation, disposal of waste, as well as their disposal at the industrial waste landfill in Pavlodar. The landfill in question is intended for the reception, temporary storage and disposal of non-hazardous solid industrial waste of the «green» level: waste and scrap of chromium, cadmium, aluminum, copper, lead, zinc, manganese, plastic waste, polyethylene, abrasive, rubber waste, ash and ash and slag waste; and also «amber»: waste containing mercury, arsenic, lead, waste batteries, phosphoric slags, waste oils, oil sludge. The scheme of organizing waste storage works is considered. The volume of accepted and recycled waste, as well as those placed at the landfill and used for their own needs, was analyzed, including construction waste, waste sleepers, ash and slag and abrasive scrap. The solution to the problem of industrial waste disposal is associated with the need for innovation and the introduction of new technologies and equipment.

The work is intended to determine the etiopathogenetic principles of animal prevention in gynecological pathology and issue a theoretical justification. At the same time, improving preventive measures aimed at preserving their health, increasing the productivity of animals in modern conditions of animal husbandry and ensuring high productivity of cows. In this regard, the main task is to develop ways to increase insemination of cows with the use of complex and homeopathic treatment. For the first time in the East Kazakhstan region, new scientific data on the main etiological factors leading to gynecological pathology and infertility of cows were obtained. Work has been carried out to improve measures aimed at preventing infertility of cows in the conditions of dairy farming in this region and stimulating increased insemination. New schemes for stimulating increased insemination using hormonal, homeopathic and other drugs have been tested. As a result, an increase in the productivity of cows was revealed, and stimulation schemes were introduced. For the first time in the farm" kamyshinskoye" an economic assessment of the damage from infertility of cows is given. Research work is done between 2016 and 2019 years by the Department of veterinary medicine of the State University named after Shakarim, in the laboratory "Agrotechnopark" of the State University named after Shakarim and national University of veterinary medicine and biotechnology named after Lviv and in the farm "kamyshinskoye" of the Shemonaikha district of East Kazakhstan region. To enhance the insemination of cows 3 groups of animals was obtained: animals of group I were not subjected to insemination; animals of group II for 1-3 hours before insemination grafted surfagon 3 ml (15 mg), 15 ml of Catosal, 15 ml habilita-Se, 10 ml uteroton; 8 days prior to insemination progesterone 2,5% 2 ml, Catosal 15 ml, habilita-Se 15 ml; cows of group III for 30-60 minutes before insemination were given Ovariovitis, and after fertilization Ovariovitis for 25-30 days and liarcine 5 ml. According to the results of drawings based on complex and homeopathic preparations, low costs were shown.

The main task of microbiological study of pulmonary patients is to identify the etiology of acute and exacerbation of chronic disease in order to determine therapy and control its effectiveness. Classical methods of microbiological research consist in isolating a pure culture of the causative agent of the disease with its identification by biochemical, antigenic and other characteristics. Such studies are multistage; they impose rather strict requirements on the quality of the source material, the timing and conditions of its transportation, laboratory equipment and the precise execution of the research methodology for at least 3-5 days. Isolation of the culture of a number of pathogens (atypical intracellular microflora, anaerobic bacteria, mycobacterium tuberculosis) requires even more lengthy studies using special media and equipment. This article presents the results of a bacteriological study of pathogenic microflora in diseases of the respiratory system of the population of the Shcherbakty district of Pavlodar region for 2017-2019, including the following sequence: microscopy of native and Gram stained smears; inoculation of biological material on nutrient media for isolation and identification of the pathogen; determination of the sensitivity of the isolated microorganism to antibiotics; immunological (serological) research methods aimed at determining antigens of microbiological origin, as well as antibodies to them in the patient's body. It has been shown that conducting bacteriological studies in accordance with the requirements of regulatory documents allows obtaining reliable and comparable results necessary both for the optimal treatment of patients and for collecting and analyzing data on monitoring the emergence and spread of diseases of the respiratory system caused by pathogenic microflora.

Main problem: The article analyzes water quality assurance as the main goal of preserving human health. The study of chemical and microbiological parameters of wastewater and drinking water was carried out using generally accepted standards. The number of deaths associated with the use of contaminated drinking water, according to WHO, tripled in 2021 and reached almost 19 thousand against 6 thousand in 2020. In addition, the number of neoplasms, diseases of the genitourinary system, digestive organs and skin increased by 2 %, to 1.486 million. The reasons for the increase in the level of harmful chemicals and microbiological pollutants in the water are outdated sewage treatment plants, old pipes and disinfection with chlorine. Purpose: Study of the quality of wastewater and drinking water in Pavlodar, study of the quality of wastewater and drinking water in Pavlodar. Methods: Sampling of wastewater, chemical and bacteriological analysis of wastewater and drinking water, statistical method, correlation analysis of experimentally obtained results and calculated characteristics, etc. Results and their significance: In the field of public health risk, pollution of reservoirs that are sources of household drinking water supply and recreational water use, the continuing necessary high deterioration of water supply networks, their accident rate, as a result of low level of operation, failures in the operation of treatment facilities. Hygienic assessment of reservoirs according to complex indicators indicates the continuing high degree of water pollution in places of water use. The water quality indicators of the surface reservoirs of the region remain low in terms of sanitary and chemical (primarily organoleptic and general sanitary), as well as microbiological indicators. According to toxicological indicators, the level of water pollution in places of water use is estimated as moderate. The main pollutants of the Irtysh River in Pavlodar are industrial enterprises and housing and communal facilities that discharge untreated or insufficiently treated wastewater into reservoirs. A complex of causes of drinking water pollution has been identified: high deterioration of water supply networks, their accident rate, because of a low level of operation, failures in the operation of treatment facilities, unfair treatment of industrial wastewater by industrial enterprises of Pavlodar, etc. Priority preventive directions for improving the quality of water as a source of life are the implementation of long-term targeted planning of measures for the modernization of water supply and sewerage networks and facilities in Pavlodar. The state of water supply necessary and measures to improve it should be constantly monitored and considered at meetings of sanitary and anti-epidemic commissions.

The variety of species and forms of parasites of agricultural animals and the features of their life cycles are the basic foundation for the production of different types and medical forms of antiparasite medicine. In the treatment of the parasitic diseases of agricultural animals, one of the main factors is that the veterinary doctors have the knowledge on the mechanics, efficiency and the safety for humans and environment of the medicine being used. Taking into account high pathogenicity and resistance of parasitic organisms and their ability to adapt to effect of medicine, it is crucial to permanently monitor the efficiency of the applied anthelmintic drugs, including the new drugs offered by veterinary services. This article will describe the results of the research on pharmacodynamic and pharmacokinetic parameters of «Ivermectinum», «Ivermec», «Aversect-1», «Аvrsect-2», «Аivin» drugs and their methods of application with the consideration of terms of maintenance and immune status of cattle herds in Mayconyr village (Irtysh district, Pavlodar region). A comparative analysis of efficiency of the above mentioned drugs in dehelmintization and treatment of cattle was conducted with the results provided. The recommendations and the restrictions on use of the drugs were determined considering the farm condition. The experimental research of the aforementioned broad-spectrum drugs was conducted strictly following the rules of asepsis and instructions on application. The total number of replacement heifers subjected to the dehelmintization under the method of analogues is 150 units. Anthelmintic treatment was conducted two times a year - in springtime (March-April) before pasturage, and fall time (September-October) before confining the cattle in the stable. Coprological study on intestinal helminthes of the examined cattle was conducted in Irtysh RVL of the Pavlodar regional branch of RVE RVL VCaSC MA RK by ovoscopical, flotation and larvoscopical methods. There is a comparative analysis on the efficiency of avermectin group antiparasitic drugs applied twice a year for cattle dehelmintization. The recommendations on the use of the aforementioned drugs for dehelmentization and prevention of parasitic diseases are provided and the requirements for the use were determined.

In modern conditions, the problem of the incidence of cows with high productivity in the postpartum period is relevant. It is these animals that are more susceptible to various diseases, primarily due to violations of the technology of keeping and feeding, weak body resistance, heavy loads during fruiting and milk production. It is known that as a result of various metabolic disorders, calving of cows in farms proceeds with various deviations. The lack of calcium in the blood due to hormonal disorders leads to hypocalcemia and paresis after calving, which is often the cause of death of animals. Therefore, the improvement of prevention schemes and treatment of puerperal paresis in cows is very relevant. Purpose of the article – Improvement of preventive and therapeutic measures for postpartum paresis in cows on the basis of the Tassu farm in Akmola district. The work was carried out under production conditions on a livestock farm in the Akmola region, in the farm "Tassu" in the spring and summer. The object of the study were black-motley cows with a pregnancy period of 250-260 days. 22 animals were selected in the experimental group, 12 animals in the control group. The average weight of animals is 567 ± 34.5 kg, age 5-6 years. The cows of the experimental group received injections of the drug Karsulen, which included: 2 % Cardus marianus D3, 1 % Sulfur D6 and 1 % Arsenycum album D6. Karsulen was administered to cows intramuscularly or subcutaneously at the rate of 1 ml per 100 kg of animal weight, the dose volume should not be less than 5 ml per animal. In the postpartum period, in the complex therapy of postpartum paresis in cows, Karsulen is used intramuscularly or subcutaneously 1-2 times a day. The use of the drug Karsulen with the composition: 1 % Cardus marianus D3, 1 % Sulfur D6 and 1 % Arsenycum album D6 has a regulatory effect on protein, carbohydrate, fat metabolism, restores impaired function of the gastrointestinal tract, liver and kidneys.

Injuries among domestic animals account for 50-70 % of all non-communicable diseases. Fractures of bones, mainly limbs, occur in 44.5 % of cases. The main goal of fracture treatment is to restore normal function and movement of the limb, and the ways in which this is done are varied. Preference is given to methods that do not constrain the movement of the limb, allowing the animal to use it during the treatment period. Purpose: This article discusses the method of bone osteosynthesis, which has proven itself in the treatment of bone fractures, and is relevant today in veterinary medicine. The main study was conducted on the basis of the veterinary clinic "Shans" in Pavlodar. For osteosynthesis, plates for osteosynthesis and screws made of titanium alloy were used. This is due to the fact that when in contact with each other, the metal that fixes bone fragments can oxidize. Animals come to the clinic as a result of injuries that lead to fractures. The most common causes include falls from a height, motor vehicles, careless or rough handling of animals, and contact with other animals. When a fracture is established by obvious signs or if a fracture is suspected, such patients are preliminarily sent for x-rays. Upon receipt of an X-ray image and with the consent of the owner of the animal, osteosynthesis is performed. When accessing bone fragments, the incision was made along the muscle fibers. Osteosynthesis was performed according to the method described by V.M. Shapovalov (2009). The general condition of the animals after osteosynthesis was restored after 3-5 days. All animals, after bone osteosynthesis, completely relied on the limb. Contractures of adjacent joints and muscle atrophy were not determined. Plain osteosynthesis of the femur, in the presence of the necessary instrument and consumables, is not very difficult to perform. Performing bone osteosynthesis in the early stages makes it possible to include the limb in the locomotory act, as a result of which the animal actively uses the limb during the rehabilitation period.

The degree of dаmаge to deer by the lаrvаe of Oedemаgenа tаrаndi of the Hypodermаtidаe fаmily depends on the number of femаles of the subcutаneous gаdfly in the summer. For the development of meаsures to combаt deer gаdflies, vаrious methods hаve been tested over the yeаrs, аmong them methods of wаtering аnd externаl locаl аpplicаtion. For this purpose, mаny reseаrchers tested dipterex (80 %), crystаlline chlorophos (97 %) in the form of аn 8 % solution, tiguvon, ricifon, dioxаfos, sulfidophos-20 аnd ectopor (2 % cypermethrin) аnd other drugs. Vаrbeks 35 %, Bаytex-50, Fenthion-50, Nаtаsol аnd Etаcid, etc. were tested intrаmusculаrly in vаrious doses on deer. The purpose is to study the prevаlence аnd effectiveness of the treаtment of edemаgenosis in sikа deer in the Ussuriysk urbаn district. The reseаrch wаs cаrried out аt the deer fаrm "Borisovskаyа". For the experiment, three groups of deer were formed with 6 heаds eаch. In order to study the therаpeutic аnd prophylаctic efficаcy of the two groups of drugs Аversect-2 аnd Dectomаx, the аnimаls of the first experimentаl group were injected with the drug Аversect-2 subcutаneously аt the rаte of 1 ml per 50 kg of аnimаl weight, deer of the second experimentаl group were injected subcutаneously with Dectomаx аt а dose of 0.2 mg per 1 kg of mаss, which corresponds to 1 ml of solution per 50 kg of mаss. The prepаrаtions were аdministered immediаtely аfter the end of the summer of gаdflies (end of July-beginning of Аugust). The third group of deer did not receive drugs, аnd it remаined the control group. The incidence of sikа deer entomosis in the Ussuriysk urbаn district for three yeаrs wаs quite high аnd remаined аt the sаme level for аlmost the entire period (43.21-48.8), with а slight decreаse in 2021 to 37.4 %, which wаs most likely due to the climаtic conditions of this period. Of the two selected drugs with seemingly the sаme spectrum of аction, the best results were obtаined on the deer of the second experimentаl group, where the drug "Dektomаx" wаs used, while the EI wаs significаntly (two times) lower thаn in the first experimentаl group аnd аmounted to 16.7 % versus 33. 3 %, аnd АI - 0.03, аgаinst 0.83.

In order to successfully conduct agricultural work and obtain a competitive harvest, it is mandatory to carry out spraying operations of crops that require highly qualified personnel, expensive equipment and suitable weather conditions. The use of tractors for spraying fields is the most common solution available at the moment, has disadvantages: high cost, risk of damage to the crop by "hitting", "hooking" or otherwise; environmental damage; due to exhaust gases, the demolition of the solution increases with increasing speed. Using a device designed specifically for spraying equipment is an ideal solution. The purpose of the article is to develop a working model of an automated sprayer for processing agricultural crops. The methods used are: technical justification of a controlled device for processing agricultural crops. Calculation of functional capabilities, algorithms of operation of the proposed automated device: selection of the type of sprayer, engine, chassis, controller, battery, as well as justification of the possibilities of using alternative energy sources (wind energy, solar energy); development of a 3D model of an automation device for anti-weed processing of agricultural crops, printing of parts, assembly of mechanical and electronic parts. Making a prototype using 3D printing; development of the wiring diagram of electronics, software (firmware of the microcontroller; application that controls the settings), testing of the prototype, assembly of the current model; rationale for the optimal use of Arduino and Raspberry Pi boards in this device in a pair: Raspberry Pi will allow you to control processes on the Arduino and easily interact with the Internet when the Arduino itself will perform simple operations such as interacting with electronics and reading sensor readings. The manufactured operating model showed compliance with the goals, a high degree of controllability, environmental friendliness, reduction of energy consumed, labor resources and can be used to scale this device. The developed model of the automation device for anti-weed treatment of agricultural crops can be used not only in agricultural pollination, but also as a mechanism for studying soil parameters: humidity, mineralogical composition and chemical content in the ground, using electronic sensors, as well as an automated mobile platform for any purpose requiring accurate navigation through the territory.