This article presents a comparative analysis of nutrient media for the cultivation of lactic acid bacteria Lactobacillus casei BM-4/17 B-RKM 0746 in a bioreactor. The main criteria for identifying the effectiveness of the nutrient medium were the accumulation of the highest biomass of lactic acid bacteria cells and the amount of nutrient medium components in relation to the biomass obtained.

This article describes the main functions of personnel management that are implemented in the formation and development of labor potential. The assessment of the labor potential of Aksu su Arnasy is given, the stages of the process of formation and development of the enterprise's labor potential are considered. The analysis of staff planning and training, as well as the process of forming a personnel reserve, was carried out.

The production of vaccine preparations before release requires standardization of their immunobiological parameters, especially safety and immunogenic efficacy. An indicator of the immunogenic effectiveness of the lumpy skin disease vaccine is the resistance of vaccinated cattle against the virulent virus. However, according to preliminary studies, the virulent control virus did not always cause clinical disease with characteristic symptoms when infected subcutaneously. The purpose is to develop a biological model in the form of a complex consisting of a pathogenic virus, a method of infection and a susceptible animal to assess the immunogenicity of a lumpy skin disease vaccine. Local cattle, intact from lumpy dermatitis, were used to reproduce lumpy dermatitis and develop the causative agent of the disease. As the initial infectious virus, we used a 20 % tissue suspension of nodules (skin nodules) obtained from cattle that fell ill with lumpy dermatitis in the field in the Atyrau region in 2016. As a viral mass to control immunogenicity, a 20 % suspension of skin nodules and edematous skin tissue at the site of the pathogen injection, obtained after the “refreshment” of the virus in animals, were used. The disease was reproduced by infection with the test suspension of the virus intradermally, subcutaneously, intravenously at a dose of 0.5 cm3 and titration on the skin of the animal. The effectiveness of the biological model was assessed by morbidity, severity of the course and severity of the manifestation of the disease. During primary intradermal infection with a field isolate of the virus, the disease manifested itself in one of three animals in the form of hyperthermia, depression, lacrimation, and the appearance of several nodular nodules in the skin of animals. The refreshed tissue virus caused clinical disease both in subcutaneous, intradermal and intravenous infection. But the clinical signs of the disease were more pronounced with intradermal inoculation of the virus, and with intravenous inoculation, it manifested itself in a more severe form with a fatal outcome. Inoculation of the virus intradermally into different areas of the skin led to the development of an independent skin lesion in each infected point in the form of painful edema, followed by necrosis, the size and intensity of which depended on the dose of the injected virus. This development of skin pathology made it possible to work out a method for determining the virus titer in vivo. The tissue virus obtained from the edematous tissue at the site of the pathogen injection was guaranteed to cause clinical disease in cattle during intradermal inoculation and made it possible to evaluate the immunogenic efficacy of the produced batches of vaccine against lumpy dermatitis.

The ideas of accelerated disclosure of the spiritual, intellectual and professional potential of a person have always been occupied by scientists and teachers (Ya.A. Komensky, K.D. Ushinsky, V.A. Sukhomlinsky, Ya. Korchak, A.S. Makarenko, A. Kunanbayev, Y. Altynsarin and others). Modern innovative teachers are guided by a personality-oriented approach, the ideas of subject-subject relations, and generational cooperation. Georgian teacher Sh. A. Amonashvili wrote: «humanitarian pedagogy perceives the child by his nature. He sees the infinity of the child, understands his cosmic quality and prepares him for the service of humanity throughout his life. It establishes the personality of the child through the determination of his will and builds pedagogical systems, the procedural of which predetermines love, optimism and high spiritual morality. Humanitarian pedagogical thinking seeks to take on something enormous, and this is the power of educational systems and processes that have arisen in its bowels». In order to realize the value of self-disclosure of innovative abilities of students, ensuring the role of a teacher, it is necessary to recognize the intellectual reflexive mechanism of a person as the main subject of Education. The purpose of the article is to identify innovative methods and models of pedagogical activity for the cultivation of innovative abilities of students, which determine the development of the country. The study used methods such as analysis, generalization, synthesis, modeling of scientific sources.